GTX11348
beta Catenin antibody [15B8] (Cy3)
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX11348
- Zusätzliche Namen:
- catenin beta 1 , CHBCAT
- Anwendung:
- WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Avian
- Aufreinigung:
- Purified
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Canine, Human
- Buffer:
- PBS, 1% BSA, 15mM Sodium azide.
- Immunogen:
- recombinant chicken B Beta-catenin.
- Klon:
- 15B8
- Synonyme:
- beta catenin;catenin (cadherin-associated protein), beta 1, 88kDa;catenin beta-1;CHBCAT
- Weitere Details:
- The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
- Versandbedingungen:
- Blue Ice