KIDINS220 antibody [C3], C-term

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX110503
Zusätzliche Namen:: kinase D interacting substrate 220 , ARMS , SINO
Anwendung:: WB, IHC-P
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Synthetic peptide encompassing a sequence within the Intracellular domain of human KIDINS220. The exact sequence is proprietary.
Klon:: C3
Uniprot:: Q9ULH0
Synonyme:: ankyrin repeat-rich membrane-spanning protein;ARMS;kinase D-interacting substrate 220kDa;kinase D-interacting substrate of 220 kDa;SINO;VENARG
Weitere Details:: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Versandbedingungen:: Blue Ice