FGD4 antibody [N1N3]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX109859
Zusätzliche Namen:: FYVE, RhoGEF and PH domain containing 4 , CMT4H , FRABP , ZFYVE6
Anwendung:: WB, IHC-P, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human FGD4. The exact sequence is proprietary.
Klon:: N1N3
Uniprot:: Q96M96
Synonyme:: Actin filament-binding protein frabin;actin-filament binding protein frabin;CMT4H;FGD1 family, member 4;FGD1-related F-actin-binding protein;FRABP;FYVE, RhoGEF and PH domain-containing protein 4;ZFYVE6;zinc finger FYVE domain-containing protein 6
Weitere Details:: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq]

Versandbedingungen:: Blue Ice