GTX109786
HSD11B2 antibody [N2C3]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX109786
- Zusätzliche Namen:
- hydroxysteroid 11-beta dehydrogenase 2 , AME , AME1 , HSD11K , HSD2 , SDR9C3
- Anwendung:
- IHC-Fr
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Ovine
- Buffer:
- 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human HSD11B2. The exact sequence is proprietary.
- Klon:
- N2C3
- Uniprot:
- P80365
- Synonyme:
- -HSD11 type II;11-beta-HSD type II;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type 2;11-beta-hydroxysteroid dehydrogenase type II;11-DH2;11-HSD type II;AME;AME1;corticosteroid 11-beta-dehydrogenase isozyme 2;HSD11K;HSD2;NAD-dependent 11-beta-hydroxysteroid dehydrogenase;SDR9C3;short chain dehydrogenase/reductase family 9C member 3
- Weitere Details:
- There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice