GTX109570
NCF4 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX109570
- Zusätzliche Namen:
- neutrophil cytosolic factor 4 , CGD3 , NCF , P40PHOX , SH3PXD4
- Anwendung:
- WB
- Konzentration:
- 0.87 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Full length human NCF4 Recombinant protein.
- Uniprot:
- Q15080
- Synonyme:
- CGD3;NCF;NCF-4;neutrophil cytosol factor 4;neutrophil cytosolic factor 4, 40kDa;neutrophil NADPH oxidase factor 4;p40-phox;P40PHOX;SH3 and PX domain-containing protein 4;SH3PXD4
- Weitere Details:
- The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice