GTX10880
PHD3 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX10880
- Zusätzliche Namen:
- egl-9 family hypoxia inducible factor 3 , HIFP4H3 , HIFPH3 , PHD3
- Anwendung:
- ChIP, WB, IHC-P, IF, ICC, IP
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- A synthetic peptide made to the C-terminus of humanPHD3/HIF Prolyl Hydroxylase 3. [LocusLink ID 112399]
- Uniprot:
- Q9H6Z9
- Synonyme:
- HIF-PH3;HIF-prolyl hydroxylase 3;HIFP4H3;HIFPH3;HPH-1;HPH-3;hypoxia-inducible factor prolyl hydroxylase 3;PHD3;prolyl hydroxylase domain-containing protein 3;prolyl hydroxylase EGLN3
- Weitere Details:
- Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.
- Versandbedingungen:
- Blue Ice