PPP4C antibody [N1], N-term

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX108299
Zusätzliche Namen:: protein phosphatase 4 catalytic subunit , PP-X , PP4 , PP4C , PPH3 , PPP4 , PPX
Anwendung:: WB, IHC-P, IF, ICC
Konzentration:: 0.45 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human PPP4C. The exact sequence is proprietary.
Klon:: N1
Uniprot:: P60510
Synonyme:: epididymis secretory sperm binding protein;PP-X;PP4;PP4C;PPH3;PPP4;PPX;protein phosphatase 4 (formerly X), catalytic subunit;Protein phosphatase X;protein phosphatase X, catalytic subunit;serine/threonine-protein phosphatase 4 catalytic subunit
Weitere Details:: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.

Versandbedingungen:: Blue Ice