GTX10778
IL10 Receptor beta antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX10778
- Zusätzliche Namen:
- interleukin 10 receptor subunit beta , CDW210B , CRF2-4 , CRFB4 , D21S58 , D21S66 , IL-10R2
- Anwendung:
- ELISA, Flow Cytometry, WB, Neutralisation
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Human
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Recombinant fragment (Human).
- Uniprot:
- Q08334
- Synonyme:
- CDW210B;CRF2-4;CRFB4;cytokine receptor class-II CRF2-4;cytokine receptor class-II member 4;cytokine receptor family 2 member 4;cytokine receptor family II, member 4;D21S58;D21S66;IL-10 receptor subunit beta;IL-10R subunit 2;IL-10R subunit beta;IL-10R2;IL-10RB;interleukin 10 receptor, beta;interleukin-10 receptor subunit 2;interleukin-10 receptor subunit beta
- Weitere Details:
- Interleukin 10, initially named cytokine synthesis inhibitory factor (CSIF), is a potent immunosuppressant of macrophage functions. IL10, a pleiotropic cytokine, exerts either immunostimulatory or immunosuppressive effects on a number of cell types, including Thy2 cells, activated fetal thymocytes, macrophages, keratinocytes, and LY-1 (CD5+) and normal B cells. IL10 stimulates the growth of stem cells, mast cells, and thymocytes and also enhances cytotoxic T cell development, costimulates B cell differentiation, and immunoglobulin secretion. Interleukin 10 binds specifically and with high affinity to cell surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. The human interleukin 10 receptor gene maps to chromosome 11q23.3.7
- Versandbedingungen:
- Blue Ice