DENND1B antibody [N1C1]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX107160
Zusätzliche Namen:: DENN domain containing 1B , C1ORF18 , C1orf218 , FAM31B
Anwendung:: WB, IF, ICC
Konzentration:: 0.9 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human DENND1B. The exact sequence is proprietary.
Klon:: N1C1
Uniprot:: Q6P3S1
Synonyme:: C1ORF18;C1orf218;connecdenn 2;DENN domain-containing protein 1B;DENN/MADD domain containing 1B;FAM31B;family with sequence similarity 31, member B;Protein FAM31B
Weitere Details:: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM]