GTX10615
EphA8 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX10615
- Zusätzliche Namen:
- Eph receptor A8 , AW047546 , Eek , Hek3 , mKIAA1459
- Anwendung:
- ELISA, WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, no preservatives.
- Immunogen:
- purified recombinant mouse EphA8 extracellular domain.
- Uniprot:
- O09127
- Synonyme:
- AW047546;Eek;Eph;EPH- and ELK-related kinase;ephrin type-A receptor 8;Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase);Hek3;mKIAA1459;tyrosine-protein kinase receptor EEK
- Weitere Details:
- EphA8, also known as Eek and Hek3, is a member of the Eph receptor family, which binds members of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region is a juxtamembrane region with two tyrosines, the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the C-terminus, the latter including one conserved tyrosine. The calculated molecular mass of the reduced mouse EphA8/Fc monomer is 84.2 kDa, but as a result of glycosylation, recombinant EphB8/Fc migrates as an approximately 100-120 kDa protein under reducing conditions in SDS-PAGE. Ligand recognition and binding leads to activation of the intrinsic kinase activity. EphA8 binds to Ephrin-A2, Ephrin-A3, and Ephrin-A5. Full length human and rat homolgs have not been successfully cloned. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation.The ephrin ligands and eph receptors display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands. Ephs and ephrins play a significant role in angiogenesis.
- Versandbedingungen:
- Blue Ice