alpha 1 Catenin antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX106014
Zusätzliche Namen:: catenin alpha 1 , CAP102 , MDPT2
Anwendung:: WB, IHC-P, IP
Konzentration:: 1.11 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Canine, Human, Mouse, Rat, Feline
Buffer:: PBS, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human alpha 1 Catenin. The exact sequence is proprietary.
Uniprot:: P35221
Synonyme:: Alpha E-catenin;alpha-E-catenin;Cadherin-associated protein;CAP102;catenin (cadherin-associated protein), alpha 1, 102kDa;catenin alpha-1;epididymis secretory sperm binding protein;MDPT2;renal carcinoma antigen NY-REN-13
Weitere Details:: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Versandbedingungen:: Blue Ice