GTX10510
RENT1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX10510
- Zusätzliche Namen:
- UPF1 RNA helicase and ATPase , HUPF1 , NORF1 , RENT1 , pNORF1 , smg-2
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Tris-Citrate/Phosphate, 0.09% Sodium azide.
- Immunogen:
- The immunogen recognized by this antibody maps to a region between residue 250 and 300 of human Regulator of Nonsense Transcripts 1 (up-frameshift mutation 1 homolog) using the numbering given in entry NP_002902.2 (GeneID 5976).
- Uniprot:
- Q92900
- Synonyme:
- ATP-dependent helicase RENT1;delta helicase;HUPF1;nonsense mRNA reducing factor 1;NORF1;pNORF1;regulator of nonsense transcripts 1;RENT1;smg-2;smg-2 homolog, nonsense mediated mRNA decay factor;up-frameshift mutation 1 homolog;up-frameshift suppressor 1 homolog;UPF1 regulator of nonsense transcripts homolog;UTF;yeast Upf1p homolog
- Weitere Details:
- This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice