GTX105038
DAG1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX105038
- Zusätzliche Namen:
- dystroglycan 1 , 156DAG , A3a , AGRNR , DAG , LGMDR16 , MDDGA9 , MDDGC7 , MDDGC9
- Anwendung:
- WB, IHC-P, IF, ICC
- Konzentration:
- 1.25 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat, Equine
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the Extracellular domain of human DAG1. The exact sequence is proprietary.
- Uniprot:
- Q14118
- Synonyme:
- 156DAG;A3a;AGRNR;DAG;dystroglycan;dystroglycan 1 (dystrophin-associated glycoprotein 1);Dystrophin-associated glycoprotein 1;LGMDR16;MDDGA9;MDDGC7;MDDGC9
- Weitere Details:
- Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice