GTX104889
CTDSP2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX104889
- Zusätzliche Namen:
- CTD small phosphatase 2 , OS4 , PSR2 , SCP2
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human CTDSP2. The exact sequence is proprietary.
- Uniprot:
- O14595
- Synonyme:
- carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2;conserved gene amplified in osteosarcoma;CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2;NLI-interacting factor 2;nuclear LIM interactor-interacting factor 2;OS4;protein OS-4;PSR2;SCP2;small C-terminal domain phosphatase 2;small CTD phosphatase 2
- Weitere Details:
- Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
- Versandbedingungen:
- Blue Ice