CD137 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX10459
Zusätzliche Namen:: TNF receptor superfamily member 9 , 4-1BB , CD137 , CDw137 , ILA
Anwendung:: ELISA, Flow Cytometry, WB, IF, ICC
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Goat
Reaktivitäten:: Human
Buffer:: PBS, 5% Trehalose, no preservatives.
Immunogen:: mouse myeloma cell line NS0-derived recombinant human 41BB/TNFRSF9/CD137 Leu24Gln186
Uniprot:: Q07011
Synonyme:: 4-1BB;4-1BB ligand receptor;CD137;CD137 antigen;CDw137;homolog of mouse 4-1BB;ILA;induced by lymphocyte activation (ILA);interleukin-activated receptor, homolog of mouse Ly63;receptor protein 4-1BB;T cell antigen ILA;T-cell antigen 4-1BB homolog;T-cell antigen ILA;tumor necrosis factor receptor superfamily member 9
Weitere Details:: CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Versandbedingungen:: Blue Ice