DUSP1 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX101229
Zusätzliche Namen:: dual specificity phosphatase 1 , CL100 , HVH1 , MKP-1 , MKP1 , PTPN10
Anwendung:: WB
Konzentration:: 0.2 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human, Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Mouse
Buffer:: PBS, 10% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human DUSP1. The exact sequence is proprietary.
Uniprot:: P28562
Synonyme:: CL 100;CL100;dual specificity protein phosphatase 1;dual specificity protein phosphatase hVH1;HVH1;MAP kinase phosphatase 1;mitogen-activated protein kinase phosphatase 1;MKP-1;MKP1;protein-tyrosine phosphatase CL100;PTPN10;serine/threonine specific protein phosphatase
Weitere Details:: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq]

Versandbedingungen:: Blue Ice