GTX101117
Neuregulin-1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX101117
- Zusätzliche Namen:
- neuregulin 1 , ARIA , GGF , GGF2 , HGL , HRG , HRG1 , HRGA , MST131 , MSTP131 , NDF , NRG1-IT2 , SMDF
- Anwendung:
- WB, IF, ICC
- Konzentration:
- 0.96 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.1M Tris, 0.1M Glycine, 10% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the Extracellular domain of human Neuregulin-1. The exact sequence is proprietary.
- Uniprot:
- Q02297
- Synonyme:
- acetylcholine receptor-inducing activity;ARIA;GGF;GGF2;glial growth factor 2;heregulin, alpha (45kD, ERBB2 p185-activator);HGL;HRG;HRG1;HRGA;MST131;MSTP131;NDF;neu differentiation factor;NRG1-IT2;pro-neuregulin-1, membrane-bound isoform;pro-NRG1;sensory and motor neuron derived factor;SMDF
- Weitere Details:
- Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice