Drosha antibody [GT1178]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX09511
Zusätzliche Namen:: drosha ribonuclease III , ETOHI2 , HSA242976 , RANSE3L , RN3 , RNASE3L , RNASEN
Anwendung:: WB, IF, ICC
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: A synthesized peptide derived from hmuan Drosha
Klon:: GT1178
Uniprot:: Q9NRR4
Synonyme:: drosha, double-stranded RNA-specific endoribonuclease;ETOHI2;HSA242976;nuclear RNase III Drosha;p241;Protein Drosha;putative protein p241 which interacts with transcription factor Sp1;putative ribonuclease III;RANSE3L;ribonuclease 3;Ribonuclease III;ribonuclease type III, nuclear;RN3;RNase III;RNASE3L;RNASEN
Weitere Details:: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a hmuan cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in hmuan patients with kidney cancer. [provided by RefSeq, Sep 2016]

Versandbedingungen:: Blue Ice