GTX05082
Caspase 12 antibody [ARC58203]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX05082
- Zusätzliche Namen:
- CASP12,CASP12P1,caspase 12 (gene/pseudogene),Caspase 12
- Anwendung:
- ELISA, WB, IHC-P
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.05% BSA, 50% Glycerol, Proclin300 or Sodium Azide.
- Immunogen:
- A synthetic peptide of human caspase 12: MADEKPSNGVLVHMVKLLIKTFLDGIFDDLMENNVLNTDEIHLIGKCLKFVVSNAENLVDDITETAQIAGKIFREHLWNSKKQLSSDISSDGEREANMPG
- Klon:
- ARC58203
- Uniprot:
- Q6UXS9
- Synonyme:
- CASP-12;CASP12P1;caspase 12 pseudogene 1;inactive caspase-12
- Weitere Details:
- Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
- Versandbedingungen:
- Blue Ice