GTX04947
NEIL2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX04947
- Zusätzliche Namen:
- NEH2,NEI2,NEIL2,nei like DNA glycosylase 2
- Anwendung:
- WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 150mM NaCl, 50%Glycerol, 0.02% Sodium Azide.
- Immunogen:
- A synthesized peptide derived from human NEIL2(Accession Q969S2), corresponding to amino acid residues G128-Y178.
- Uniprot:
- Q969S2
- Synonyme:
- DNA glycosylase/AP lyase Neil2;DNA-(apurinic or apyrimidinic site) lyase Neil2;endonuclease 8-like 2;Endonuclease VIII-like 2;NEH2;nei endonuclease VIII-like 2;nei homolog 2;nei-like protein 2;NEI2
- Weitere Details:
- This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
- Versandbedingungen:
- Blue Ice