GTX04895
SMAD1+5+8(9) antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX04895
- Zusätzliche Namen:
- BSP1,JV41,MADH1,MADR1,SMAD family member 1,SMAD1,Smad1,DWFC,JV51,MADH5,SMAD family member 5,SMAD5,MADH6,MADH9,PPH2,SMAD family member 9,SMAD8,SMAD8/9,SMAD8A,SMAD8B,SMAD9
- Anwendung:
- WB, IHC-P, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium Azide.
- Immunogen:
- A synthesized peptide derived from human SMAD1(Accession Q15797), corresponding to amino acid residues I438-S465. Sequence homology: Smad1, Smad5, Smad8, Smad9.
- Uniprot:
- O15198, Q15797, Q99717
- Synonyme:
- BSP-1;BSP1;DWFC;JV4-1;JV41;JV5-1;MAD homolog 9;Mad-related protein 1;MAD, mothers against decapentaplegic homolog 1;MAD, mothers against decapentaplegic homolog 5;MADH1;MADH5;MADH6;MADH9;MADR1;mothers against decapentaplegic homolog 1;mothers against decapentaplegic homolog 5;mothers against decapentaplegic homolog 9;mothers against decapentaplegic, drosophila, homolog of, 5;Mothers against decapentaplegic, drosophila, homolog of, 9;mothers against DPP homolog 1;PPH2;SMA- and MAD-related protein 5;SMAD family member 1;SMAD family member 5;SMAD family member 9;SMAD, mothers against DPP homolog 1;SMAD, mothers against DPP homolog 5;SMAD, mothers against DPP homolog 9;SMAD8;SMAD8/9;SMAD8A;SMAD8B;TGF-beta signaling protein 1;transforming growth factor-beta signaling protein 1;Transforming growth factor-beta-signaling protein 1
- Weitere Details:
- The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]|The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]|The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
- Versandbedingungen:
- Blue Ice