NR0B2 antibody [OTI7B5]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX04884
Zusätzliche Namen:: NR0B2,SHP,SHP1,nuclear receptor subfamily 0 group B member 2
Anwendung:: WB, IHC-P
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium Azide.
Immunogen:: Full length human recombinant protein of human NR0B2 (NP_068804) produced in E.coli.
Klon:: OTI7B5
Uniprot:: Q15466
Synonyme:: nuclear receptor SHP;nuclear receptor subfamily 0 group B member 2;orphan nuclear receptor SHP;SHP;SHP1;small heterodimer partner
Weitere Details:: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice