GTX04533
PERK (phospho Thr982) antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX04533
- Zusätzliche Namen:
- eukaryotic translation initiation factor 2 alpha kinase 3 , PEK , PERK , WRS
- Anwendung:
- ELISA, WB, IHC-P, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified; Sequential Chromatography
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% sodium azide.
- Immunogen:
- A synthesized peptide derived from human EIF2AK3(Accession Q9NZJ5), corresponding to amino acid residues around phosphorylated Thr 982.
- Uniprot:
- Q9NZJ5
- Synonyme:
- eukaryotic translation initiation factor 2-alpha kinase 3;pancreatic EIF2-alpha kinase;PEK;PERK;PRKR-like endoplasmic reticulum kinase;truncated eukaryotic translation initiation factor 2 alpha kinase 3;WRS
- Weitere Details:
- The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
- Versandbedingungen:
- Blue Ice