GTX03656
MUS81 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX03656
- Zusätzliche Namen:
- MUS81 structure-specific endonuclease subunit , SLX3
- Anwendung:
- ELISA, WB
- Konzentration:
- 0.5 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, no preservatives.
- Immunogen:
- E.coli-derived human MUS81 recombinant protein (Position: H283-R483).
- Uniprot:
- Q96NY9
- Synonyme:
- crossover junction endonuclease MUS81;MUS81 endonuclease homolog;SLX3;SLX3 structure-specific endonuclease subunit homolog
- Weitere Details:
- This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]
- Versandbedingungen:
- Blue Ice