GTX03275
PRDM16 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX03275
- Zusätzliche Namen:
- PR/SET domain 16 , CMD1LL , KMT8F , LVNC8 , MEL1 , PFM13
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- PRDM16 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PRDM16 (1120 - 1170).
- Uniprot:
- Q9HAZ2
- Synonyme:
- CMD1LL;histone-lysine N-methyltransferase PRDM16;KMT8F;LVNC8;MDS1/EVI1-like gene 1;MEL1;PFM13;PR domain 16;PR domain containing 16;PR domain zinc finger protein 16;PR domain-containing protein 16;transcription factor MEL1
- Weitere Details:
- The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice