GTX02581
LIMK1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX02581
- Zusätzliche Namen:
- LIM domain kinase 1 , LIMK , LIMK-1
- Anwendung:
- ELISA, WB, IHC-P, IP
- Konzentration:
- 0.55 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Tris/Glycine, 0.5% BSA, 30% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Synthetic peptide taken within amino acid region 550-647 on human LIM Kinase 1 protein.
- Uniprot:
- P53667
- Synonyme:
- LIM domain kinase 1;LIM motif-containing protein kinase;LIMK;LIMK-1
- Weitere Details:
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
- Versandbedingungen:
- Blue Ice