CDC4 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX02557
Zusätzliche Namen:: F-box and WD repeat domain containing 7 , AGO , CDC4 , FBW6 , FBW7 , FBX30 , FBXO30 , FBXW6 , SEL-10 , SEL10 , hAgo , hCdc4
Anwendung:: WB, IHC-P
Konzentration:: 0.5-1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 2% Sucrose, 0.09% Sodium azide.
Immunogen:: The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7.
Uniprot:: Q969H0
Synonyme:: AGO;archipelago;Archipelago homolog;CDC4;F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase;F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila);F-box and WD-40 domain-containing protein 7;F-box protein FBW7;F-box protein FBX30;F-box protein SEL-10;F-box/WD repeat-containing protein 7;FBW6;FBW7;FBX30;FBXO30;FBXW6;hAgo;hCdc4;homolog of C elegans sel-10;SEL-10;SEL10
Weitere Details:: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Versandbedingungen:: Blue Ice