Utrophin antibody [DRP3/20C5]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX01977
Zusätzliche Namen:: utrophin , DMDL , DRP , DRP1
Anwendung:: IHC-Fr
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Unpurified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Canine, Human, Rat
Buffer:: Tissue culture supernatant, 0.09% Sodium azide.
Immunogen:: Fusion protein containing the first 261 amino acids of the published DMDL gene sequence.
Klon:: DRP3/20C5
Uniprot:: P46939
Synonyme:: DMDL;DRP;DRP1;dystrophin-related protein 1;utrophin
Weitere Details:: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice