Perforin antibody [5B10]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX01949
Zusätzliche Namen:: perforin 1 , HPLH2 , P1 , PFP
Anwendung:: IHC-P
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Unpurified
Lagerbedingungen:: 2-8[o]C Do not freeze.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: Tissue culture supernatant, 0.09% Sodium azide.
Immunogen:: Recombinant prokaryotic protein corresponding to an external region of the C-terminus of the perforin molecule.
Klon:: 5B10
Uniprot:: P14222
Synonyme:: cytolysin;HPLH2;lymphocyte pore-forming protein;P1;perforin 1 (pore forming protein);perforin-1;PFP
Weitere Details:: This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]