Geminin antibody [EM6]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX01909
Zusätzliche Namen:: geminin DNA replication inhibitor , Gem , MGORS6
Anwendung:: WB, IHC-P
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Unpurified
Lagerbedingungen:: 2-8[o]C Do not freeze.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: Tissue culture supernatant, 0.09% Sodium azide.
Immunogen:: A prokaryotic recombinant protein containing amino acids 5-209 of the mature protein.
Klon:: EM6
Uniprot:: O75496
Synonyme:: Gem;geminin;MGORS6
Weitere Details:: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]