GTX01833
TCL1A antibody [ZM92]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX01833
- Zusätzliche Namen:
- T cell leukemia/lymphoma 1A , TCL1
- Anwendung:
- IHC-P
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Purified
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- Tris-HCl, 0.2% BSA, 0.09% Sodium azide.
- Immunogen:
- Recombinant human TCL1 protein fragment (around aa 2-109)
- Klon:
- ZM92
- Uniprot:
- P56279
- Synonyme:
- oncogene TCL-1;oncogene TCL1;protein p14 TCL1;T cell leukemia/lymphoma 1A;T-cell leukemia/lymphoma protein 1A;T-cell lymphoma-1;TCL1
- Weitere Details:
- Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
- Versandbedingungen:
- Blue Ice