NUP98 antibody [2H10]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX00697
Zusätzliche Namen:: nucleoporin 98 , ADIR2 , NUP196 , NUP96
Anwendung:: ELISA, WB, IF, ICC, Dot blot
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rat
Reaktivitäten:: Human, Mouse, Rat, Yeast
Buffer:: Filter-sterilized PBS, 50% Glycerol, no preservatives.
Immunogen:: Recombinant GST-fused human Nup98 (amino acids 1-466)
Klon:: 2H10
Uniprot:: P52948
Synonyme:: ADIR2;GLFG-repeat containing nucleoporin;nuclear pore complex protein Nup98;nuclear pore complex protein Nup98-Nup96;nucleoporin 96;nucleoporin 98kD;nucleoporin 98kDa;NUP196;NUP96;Nup98-96;Nup98-Nup96;NUP98/PHF23 fusion 2 protein
Weitere Details:: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Versandbedingungen:: Blue Ice