MDMX / MDM4 (phospho Ser367) antibody [#15]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX00677
Zusätzliche Namen:: MDM4 regulator of p53 , HDMX , MDMX , MRP1
Anwendung:: ELISA, WB, IF, ICC, IP
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 50% Glycerol, no preservatives.
Immunogen:: A synthetic peptide corresponding to a sequence of human Mdmx protein surrounding phospho-Ser367
Klon:: #15
Uniprot:: O15151
Synonyme:: BMFS6;Double minute 4 protein;double minute 4, human homolog of; p53-binding protein;HDMX;mdm2-like p53-binding protein;Mdm4 p53 binding protein homolog;MDM4 protein variant G;MDM4 protein variant Y;MDM4-related protein 1;MDM4, p53 regulator;MDMX;MRP1;p53-binding protein Mdm4;protein Mdm4;protein Mdmx
Weitere Details:: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Versandbedingungen:: Blue Ice