KIR2DL5A antibody [UP-R1]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX00515
Zusätzliche Namen:: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A , CD158F , KIR2DL5 , KIR2DL5.1 , KIR2DL5.3
Anwendung:: Flow Cytometry, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein A Purified
Lagerbedingungen:: 2-8[o]C Do not freeze.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 15mM Sodium azide.
Immunogen:: Human CD158f-Ig fusion protein
Klon:: UP-R1
Uniprot:: Q8N109
Synonyme:: CD158F;killer cell immunoglobulin-like receptor 2DL5A;killer cell immunoglobulin-like receptor KIR2DL5A;killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5;killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A;KIR2DL5;KIR2DL5.1;KIR2DL5.3
Weitere Details:: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice