CD35 antibody [E11] (APC)

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX00483-07
Zusätzliche Namen:: C3BR , C4BR , CD35 , CR1 , KN , complement C3b/C4b receptor 1 (Knops blood group)
Anwendung:: Flow Cytometry
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Size-exclusion Chromatography
Lagerbedingungen:: 2-8[o]C Do not freeze. Protect from light.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 15mM Sodium azide.
Immunogen:: Acute monocytic leukemia cells and normal blood monocytes
Klon:: E11
Uniprot:: P17927
Synonyme:: C3-binding protein;C3b/C4b receptor;C3BR;C4BR;CD35;CD35 antigen;complement component (3b/4b) receptor 1 (Knops blood group);complement receptor 1;complement receptor type 1;KN;Knops blood group antigen
Weitere Details:: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice