GTX00376-PRO
Rat p53 protein, His tag
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX00376-PRO
- Zusätzliche Namen:
- tumor protein p53 , Trp53 , p53
- Anwendung:
- FuncS
- Physischer Zustand:
- Lyophilized
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Buffer:
- Reconstitute with 20mM Tris and 150mM NaCl to 0.1-1.0mg/ml. Do not vortex. Lyophilized from 20mM Tris, 150mM NaCl, 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose, ProClin 300.
- Immunogen:
- tumor protein p53
- Spezies:
- Rat
- Uniprot:
- P10361
- Synonyme:
- cellular tumor antigen p53;p53;transformation related protein 53;Trp53;tumor protein p53 (Li-Fraumeni syndrome);tumor suppressor p53
- Weitere Details:
- This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice