GTX00255-PRO
Human PAPP A protein, His tag
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX00255-PRO
- Zusätzliche Namen:
- pappalysin 1 , ASBABP2 , DIPLA1 , IGFBP-4ase , PAPA , PAPP-A , PAPPA1
- Anwendung:
- FuncS
- Physischer Zustand:
- Lyophilized
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Buffer:
- Reconstitute with 20mM Tris and 150mM NaCl to 0.1-1.0mg/ml. Do not vortex. Lyophilized from 20mM Tris, 150mM NaCl, 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose, ProClin 300.
- Immunogen:
- pappalysin 1
- Spezies:
- Human
- Uniprot:
- Q13219
- Synonyme:
- ASBABP2;aspecific BCL2 ARE-binding protein 2;differentially placenta 1 expressed protein;DIPLA1;IGF-dependent IGFBP-4 protease;IGFBP-4ase;insulin-like growth factor-dependent IGF binding protein-4 protease;Insulin-like growth factor-dependent IGF-binding protein 4 protease;PAPA;PAPP-A;PAPPA1;pappalysin-1;Pregnancy-associated plasma protein A;pregnancy-associated plasma protein A, pappalysin 1
- Weitere Details:
- This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
- Versandbedingungen:
- Blue Ice