PME30080
Human CCL16 Protein
Größe
£497.00
- SKU:
- PME30080
- Zusätzliche Namen:
- C-C Motif Chemokine 16;Chemokine CC-4;HCC-4;Chemokine LEC;IL-10-Inducible Chemokine;LCC-1;Liver-Expressed Chemokine;Lymphocyte and Monocyte Chemoattractant;LMC;Monotactin-1;MTN-1;NCC-4;Small-Inducible Cytokine A16;CCL16;ILINCK;NCC4;SCYA16
- Molekulargewicht:
- 11 KDa
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH 7.4.
- Target:
- CCL16
- Not available:
- Not available
- Weitere Details:
- CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines; showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1; CCR2; CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity; suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES; suggesting that CCL16 and RANTES share the same receptor in THP1 cells.
- Versandbedingungen:
- Ambient