Human FGFa (154AA) Protein

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£457.00

SKU:: PME30065
Zusätzliche Namen:: Fibroblast Growth Factor 1;FGF-1;Acidic Fibroblast Growth Factor;aFGF;Endothelial Cell Growth Factor;ECGFHeparin-Binding Growth Factor 1;HBGF-1;FGF1;FGFA
Molekulargewicht:: 17.3 KDa
Reinheit:: Greater than 95% as determined by reducing SDS-PAGE.
Lagerbedingungen:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Hersteller:: DIMA Biotechnology Ltd
Formulierung:: Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
Target:: FGFa
Not available:: Not available
Weitere Details:: FGF acidic; also known as ECGF; FGF-1and HBGF-1; is a non-glycosylated heparin binding growth factor that is expressed in the brain; kidney; retina; smooth muscle cells; bone matrix; osteoblasts; astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal; ectodermal; and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta; exported to the cytosol; dephosphorylated; and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.