PME30039
Human GDF-5 Protein
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£304.00
- SKU:
- PME30039
- Zusätzliche Namen:
- Growth/differentiation factor 5;GDF-5;Bone morphogenetic protein 14;BMP-14;Cartilage-derived morphogenetic protein 1;CDMP-1;Lipopolysaccharide-associated protein 4;LAP-4;LPS-associated protein 4;Radotermin;CDMP1
- Molekulargewicht:
- 13.7 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
- Target:
- GDF-5
- Not available:
- Not available
- Weitere Details:
- Growth Differentiation Factor 5(GDF-5; BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5; -6; and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1; 5; and 8). GDF-5 is involved in multiple developmental processes including limb generation; cartilage development; joint formation; bone morphogenesis; cell survival; and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
- Versandbedingungen:
- Ambient