Human IRF5 (C-6His) Protein

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£649.00

SKU:: PME30017
Zusätzliche Namen:: Interferon Regulatory Factor 5;IRF-5;IRF5
Molekulargewicht:: 57.1 KDa
Reinheit:: Greater than 95% as determined by reducing SDS-PAGE.
Lagerbedingungen:: Store at ≤-70[o]C; stable for 6 months after receipt.Store at ≤-70[o]C; stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Hersteller:: DIMA Biotechnology Ltd
Formulierung:: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl; 150mM NaCl; 30% Glycerol; 1mM DTT; pH 8.0.
Target:: IRF5
Not available:: Not available
Weitere Details:: Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition; the genetic variations wil result in susceptibility to rheumatoid arthritis.