PME30013
Human CXCL2 Protein
Größe
£599.00
- SKU:
- PME30013
- Zusätzliche Namen:
- C-X-C Motif Chemokine 2;Growth-Regulated Protein Beta;Gro-Beta;Macrophage Inflammatory Protein 2-Alpha;MIP2-Alpha;CXCL2;GRO2;GROB;MIP2A;SCYB2
- Molekulargewicht:
- 7.67 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl; 150mM NaCl; pH 8.0.
- Target:
- CXCL2
- Not available:
- Not available
- Weitere Details:
- Chemokine Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. It has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. It is a hematoregulatory chemokine; which suppresses hematopoietic progenitor cell proliferation. It can be induced by receptor activator of NF-kappaB ligand; the osteoclast (OC) differentiation factor; through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
- Versandbedingungen:
- Ambient