PME30002
Human CCL26 (68AA) Protein
Größe
£536.00
- SKU:
- PME30002
- Zusätzliche Namen:
- C-C Motif Chemokine 26;CC Chemokine IMAC;Eotaxin-3;Macrophage Inflammatory Protein 4-Alpha;MIP-4-Alpha;Small-Inducible Cytokine A26;Thymic Stroma Chemokine-1;TSC-1;CCL26;SCYA26
- Molekulargewicht:
- Predicted MW is 8.21 Kda. Protein runs at 13KDa under reducing conditions.
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C or lower; stable for one year after receipt. Reconstituted protein solution can be stored at 2-8[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C or lower for 3 months. The product is shipped at ambient temperature. Upon receipt; store it immediately at the proper temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH 7.2.
- Target:
- CCL26
- Not available:
- Not available
- Weitere Details:
- Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family; which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus; but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26; along with Eotaxin-1 and Eotaxin-2; selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines; Eotaxin-3 maps to human chromosome 7q11.2; within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
- Versandbedingungen:
- Ambient