PME101922
Human HTR1B Protein; hFc Tag
Größe
£189.00
- SKU:
- PME101922
- Zusätzliche Namen:
- 5-HT1B; 5-HT1BR; Serotonin receptor 1B; 5-hydroxytryptamine receptor 1B
- Molekulargewicht:
- The protein has a predicted molecular mass of 31.0 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- HTR1B
- HTR1B(Met1-Leu46) hFc(Glu99-Ala330):
- HTR1B(Met1-Leu46) hFc(Glu99-Ala330)
- Weitere Details:
- HTR1B (5-HT1B / Serotonin receptor 1B) is a G-protein coupled receptor (GPCR) primarily expressed in the central nervous system; including the basal ganglia; cortex; and hippocampus. It couples to Gi/o proteins; inhibiting adenylyl cyclase and reducing intracellular cAMP; while modulating MAPK signaling. HTR1B regulates neurotransmitter release; mood; aggression; and vascular tone. Dysregulation is linked to migraine; depression; anxiety; and psychiatric disorders; making HTR1B a relevant therapeutic target in neuropsychiatric and vascular conditions.
- Versandbedingungen:
- Ambient