PME101910
Human EDNRA Protein; hFc Tag
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£194.00
- SKU:
- PME101910
- Zusätzliche Namen:
- EDNRA; ETA; Endothelin receptor A; ET-A receptor; ETAR
- Molekulargewicht:
- The protein has a predicted molecular mass of 32.9 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- EDNRA
- EDNRA(Asp21-Lys80) hFc(Glu99-Ala330):
- EDNRA(Asp21-Lys80) hFc(Glu99-Ala330)
- Weitere Details:
- EDNRA (Endothelin receptor type A) is a G-protein coupled receptor (GPCR) that primarily binds endothelin-1 (ET-1). It couples to Gq/11 proteins; activating phospholipase C (PLC); increasing IP₃/DAG and intracellular Ca²⁺; and triggering smooth muscle contraction. EDNRA is expressed in vascular smooth muscle; heart; and kidney; where it regulates vasoconstriction; blood pressure; and cardiovascular function. Dysregulation of EDNRA signaling is implicated in hypertension; heart failure; and pulmonary arterial hypertension; making it a key therapeutic target in cardiovascular disease.
- Versandbedingungen:
- Ambient