PME101894
Human HTR6 Protein; hFc Tag
Größe
£194.00
- SKU:
- PME101894
- Zusätzliche Namen:
- 5-HT6; 5-HT6R
- Molekulargewicht:
- The protein has a predicted molecular mass of 28.6 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- HTR6
- HTR6(Met1-Gly27) hFc(Glu99-Ala330):
- HTR6(Met1-Gly27) hFc(Glu99-Ala330)
- Weitere Details:
- HTR6 encodes the 5-hydroxytryptamine (serotonin) receptor 6; a G-protein coupled receptor (GPCR) that primarily couples to Gs proteins; leading to activation of adenylyl cyclase and elevation of intracellular cAMP levels. It is mainly expressed in the central nervous system; particularly in the striatum; cortex; hippocampus; and olfactory tubercle; where it modulates cholinergic; dopaminergic; and glutamatergic neurotransmission. HTR6 plays important roles in cognition; learning; memory; and mood regulation. Dysregulation of HTR6 signaling has been implicated in Alzheimer’s disease; schizophrenia; and cognitive impairment; making it a potential therapeutic target for neuropsychiatric and neurodegenerative disorders.
- Versandbedingungen:
- Ambient