PME101892
EBVB9 BILF1 Protein; hFc Tag
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£189.00
- SKU:
- PME101892
- Zusätzliche Namen:
- GPCR BILF1，BLIF
- Molekulargewicht:
- The protein has a predicted molecular mass of 29.9 kDa after removal of the signal peptide.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- BILF1
- BILF1(Met1-Ser37) hFc(Glu99-Ala330):
- BILF1(Met1-Ser37) hFc(Glu99-Ala330)
- Weitere Details:
- BILF1 is a G-protein coupled receptor (GPCR) encoded by Epstein–Barr virus (EBV) and some related γ-herpesviruses. It functions as a viral GPCR homolog; mimicking host chemokine receptors. BILF1 constitutively activates Gαi signaling; leading to inhibition of cAMP accumulation and modulation of downstream pathways such as MAPK/ERK and NF-κB; thereby promoting cell survival and immune evasion. It can downregulate MHC class I molecules; reducing antigen presentation to cytotoxic T cells. Through these activities; BILF1 contributes to viral persistence and oncogenic transformation in EBV-associated malignancies.
- Versandbedingungen:
- Ambient