PME101710
Human ACVR2B(18-41) Protein; mFc Tag
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£199.00
- SKU:
- PME101710
- Zusätzliche Namen:
- HTX4; ACTRIIB; ActR-IIB
- Molekulargewicht:
- The protein has a predicted molecular mass of 29.0 kDa after removal of the signal peptide. The apparent molecular mass of ACVR2B(18-41)-mFc is approximately 25-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- ACVR2B
- ACVR2B(Gly18-Thr41) mFc(Pro99-Lys330):
- ACVR2B(Gly18-Thr41) mFc(Pro99-Lys330)
- Weitere Details:
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor; which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq; Jul 2008]
- Versandbedingungen:
- Ambient