PME101679
Human CTSL Protein; His Tag
Größe
£189.00
- SKU:
- PME101679
- Zusätzliche Namen:
- MEP; CATL; CTSL1
- Molekulargewicht:
- The protein has a predicted molecular mass of 37.2 kDa after removal of the signal peptide. The apparent molecular mass of CTSL-His is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- CTSL
- CTSL(Thr18-Val333) 10×His tag:
- CTSL(Thr18-Val333) 10×His tag
- Weitere Details:
- The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin; as well as alpha-1 protease inhibitor; a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes; including myofibril necrosis in myopathies and in myocardial ischemia; and in the renal tubular response to proteinuria. This protein; which is a member of the peptidase C1 family; is a dimer composed of disulfide-linked heavy and light chains; both produced from a single protein precursor. Additionally; this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein; which is necessary for entry of the virus into the cell. [provided by RefSeq; Aug 2020]
- Versandbedingungen:
- Ambient