PME101490
Human VEGF121 Protein; hFc Tag
Größe
£189.00
- SKU:
- PME101490
- Zusätzliche Namen:
- MVCD1; VEGF; VPF; VEGFA
- Molekulargewicht:
- The protein has a predicted molecular mass of 40.2 kDa after removal of the signal peptide. The apparent molecular mass of VEGF121-hFc is approximately 35-55 kDa due to glycosylation.
- Reinheit:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Lagerbedingungen:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Hersteller:
- DIMA Biotechnology Ltd
- Formulierung:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- VEGF121
- VEGF121(Ala27-Arg147)+hFc(Glu99-Ala330):
- VEGF121(Ala27-Arg147)+hFc(Glu99-Ala330)
- Weitere Details:
- Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor (VPF) and VEGF-A; and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects; including mediating increased vascular permeability; inducing angiogenesis; vasculogenesis and endothelial cell growth; promoting cell migration; and inhibiting apoptosis. Alternatively spliced transcript variants; encoding either freely secreted or cell-associated isoforms; have been characterized. Alternatively spliced isoforms of 121;145;165;183;189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform; followed by VEGF121 and VEGF189. VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible. Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term; and show defects in skeletogenesis. Human VEGF121 shares 87% aa sequence identity with corresponding regions of mouse and rat; 93% with feline; equine and bovine; and 91%; 95% and 96% with ovine; canine and porcine VEGF; respectively. VEGF121 induces the proliferation of lymphatic endothelial cells. The lymphangiogenesis may be promoted by upregulation of VEGF121; which may in turn act in part via induction of VEGF-C.
- Versandbedingungen:
- Ambient